Title of article :
Association Between IL-10 Gene Promoter Polymorphisms (-592 A/C, -819 T/C, -1082 A/G) and Susceptibility to HBV Infection in an Iranian Population
Author/Authors :
Moudi، Bita نويسنده Infectious Diseases and Tropical Medicine Research Center, Zahedan University of Medical Sciences, Zahedan, IR Iran , , Heidari، Zahra نويسنده Genetic of Non-communicable Diseases Research Center, Department of Histology, Zahedan University of Medical Sciences, Zahedan, Iran Heidari, Zahra , Mahmoudzadeh-Sagheb، Hamidreza نويسنده Genetic of Non-communicable Diseases Research Center, Department of Histology, Zahedan University of Medical Sciences, Zahedan, Iran Mahmoudzadeh-Sagheb, Hamidreza , Hashemi، Mohammad نويسنده , , Metanat، Malihe نويسنده , , Khosravi، Soheila نويسنده General Physician, Zahedan Blood Transfusion Centre, Zahedan, IR Iran , , Farrokh، Parisa نويسنده ,
Abstract :
IL-10 can play a vital role in immune response against HBV. Three biallelic SNPs from the transcription start site control the transcription of the IL-10 gene. An association between susceptibility to HBV and IL-10 polymorphisms has been suggested in patients with HBV infection. The present study was designed to study the association between polymorphisms in interleukin-10 (-1082 A/G, -819 T/C and -592 A/C) promoter gene and chronic hepatitis B virus (HBV) infection. 221 chronically infected patients and 200 healthy control subjects were enrolled in the study. Three biallelic (-1082 A/G, -819 T/C and -592 A/C) polymorphisms in the IL-10 promoter gene were determined by PCR-RFLP method. Persistent HBV infection was associated with IL-10-1082 AG (P = 0.001) and GG (P = 0.004) genotypes and G (P = 0.000) allele. IL-10-819 T/C and -592 A/C genotype and allele frequencies did not show any correlation with the risk of chronic hepatitis B infection. These results suggest that polymorphisms in interleukin-10 gene promoter influence clinical outcome of HBV infection and susceptibility to HBV infection.
