Author/Authors :
Shokri، Ghasem نويسنده Department of Electrical Engineering, Ardabil Branch, Islamic Azad University, Ardabil, Iran , , Fathi، Hamed نويسنده , , Jafari Sabet، Majid نويسنده Department of Pharmacology, School of Medicine, Iran University of Medical Sciences, Tehran, IR Iran , , Nasri Nasrabadi، Nafiseh نويسنده M.Sc Student Toxicology, Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran. , , Ataee، Ramin Ramin نويسنده Pharmaceutical Sciences Research Center, Department of Pharmacology and Toxicology Mazandaran University of Medical Sciences, Sari, Iran. Ataee, Ramin Ramin
Abstract :
Today diabetes is one of the most common diseases in the world that affects half of the world population. Today, the use of medicinal herbs especially green tea and cinnamon has been taken into consideration for relieving the symptoms of diabetes, but there were some different ideas about their effectiveness. So, this study was conducted to evaluate the effect of cinnamon and green tea extract, individually and in combination, on blood glucose and weight loss in diabetic mice with Streptozotocin (STZ). The experiment was performed on 50 Wistar rats. A total of 50 rats were divided into 10 groups of 5 and STZ injected at dose of 40 mg/kg/day for 5 days intraperitoneally. After diabetes induction, three groups received, 50, 100 and 200 mg doses of green tea extract, three groups received 50, 100 and 200 mg doses of cinnamon extract and three final groups received 50, 100 and 200 mg doses of cinnamon and green tea in combination by gavages daily for 6 weeks. After each period of treatments, blood glucose and the weight of animals were determined. At the end of the sixth week, blood glucose and weight loss were improved in diabetic rats in a dose-dependent manner and the dose of 200 mg/kg extract cinnamon with green tea had the most appropriate synergic effect.
