Author/Authors :
Haghdoost، Faraidoon نويسنده Medical Student Research Center AND Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran Haghdoost, Faraidoon , Gharzi، Mahsa نويسنده Isfahan Medical Students’ Research Center, Isfahan University of Medical Sciences, Isfahan, IR Iran , , Faez، Farough نويسنده Department of Pharmacognosy, Isfahan Faculty of Pharmacy and Pharmaceutical Sciences , , Hosseinzadeh، Elinaz نويسنده Medical Students’ Research Center, Isfahan University of Medical Sciences, Isfahan , , Tajaddini، Mohamadhasan نويسنده Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran Tajaddini, Mohamadhasan , Rafiei، Laleh نويسنده Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran Rafiei, Laleh , Asgari، Fatemeh نويسنده Medical Student Research Center, Isfahan University of Medical Sciences, Isfahan, Iran Asgari, Fatemeh , Banihashemi، Mahboobeh نويسنده Medical Student Research Center, Isfahan University of Medical Sciences, Isfahan, Iran Banihashemi, Mahboobeh , Masjedi، Samaneh Sadat نويسنده Medical Student Research Center, Isfahan University of Medical Sciences, Isfahan, Iran Masjedi, Samaneh Sadat , Zandifar، Alireza نويسنده Medical Student Research Center, Isfahan University of Medical Sciences, Isfahan, Iran Zandifar, Alireza , Haghjooy Javanmard، Shaghayegh نويسنده Physiology Research Center ,
Abstract :
Background: Migraine is a common neurovascular disorder with multifactorial and polygenic inheritance. The aim of this study was to investigate the association of a migraine without aura and Ala379Val polymorphism of lipoprotein-associated phospholipase A2 (Lp-PLA2) gene in the Iranian population.
Methods: In this study, 103 migraine patients and 100 healthy controls were enrolled. DNA samples were extracted and the Ala379Val polymorphism of Lp-PLA2 gene was investigated. To assess severity of a headache, patients filled out the headache impact test (HIT-6) and migraine severity (MIGSEV) questionnaires.
Results: Allele V had significantly lower frequency in the case group than control subjects [P = 0.001, odds ratio (OR) = 0.25, confidence interval (CI): 0.15-0.40]. The frequency of migraine patients that were a carrier of V allele (V/V and A/V) was statistically significant lower than the control group (P = 0.003, OR = 2.39, CI: 1.35-4.23). There was no significant difference of alleles frequency between three grades of MIGSEV (P = 0.316). Furthermore, total HIT-6 score was not significantly different between different genotypes (P = 0.466).
Conclusion: Our results showed that Ala379Val gene polymorphism of LP-PLA2 is associated with lower risk of migraine but not with severity of headaches in an Iranian population.
