Title of article :
Synthesis of Mesoporous Silica and Modified as a Drug Delivery System of Ibuprofen
Author/Authors :
Mortazavi، Y. نويسنده Babol University of Medical Sciences, pramedicine Faculty, Anesthesiology and Operation Department, Babol, Iran , , Ghoreishi، S. M. نويسنده Department of Analytical Chemistry, Faculty of Chemistry, University of Kashan, Kashan, I.R. Iran. ,
Issue Information :
فصلنامه با شماره پیاپی 0 سال 2016
Abstract :
در اين مقاله نانوذرات مزوپروس سيليكا سنتز و جهت اتصال ايبوپروفن به آن، با 3-آمينوپروپيل تري اتوكسي سيلان عامل دار شد. . نانوساختارسنتز شده با پراش اشعه X ، ميكروسكوپ الكتروني روبشي، اسپكتروسكوپي مادون قرمز و اسپكتروسكوپي UV-Vis بررسي شد. نتايج نشان داد كه با عامل دار كردن ظرفيت بارگذاري دارو افزايش . سرعت رهايش كاهش مي يابد.
Abstract :
In this work we synthesized of mesoporous silica nanoparticles and
functionalized with 3-aminopropyltriethoxysilane to improve the loading
and release of ibuprofen bonded to 3-aminopropyltriethoxysilane. sample
were characterized by Fourier transform infrared spectroscopy, Scanning
electron microscopy , X-ray diffraction, and ultraviolet-visible. the Fourier
transform infrared spectroscopy result demonstrate that organic group were
successfully functionalized onto mesoporous silica nanoparticles. Then, we
investigate of the adsorption and release of ibuprofen as a drug delivery
system in simulated body fluid. The result demonstrates that high adsorption
capacity for drug with functionalized sample and slower drug release rate was
achieved.
Journal title :
Journal of NanoStructures
Journal title :
Journal of NanoStructures