Title of article
Synthesis of Mesoporous Silica and Modified as a Drug Delivery System of Ibuprofen
Author/Authors
Mortazavi، Y. نويسنده Babol University of Medical Sciences, pramedicine Faculty, Anesthesiology and Operation Department, Babol, Iran , , Ghoreishi، S. M. نويسنده Department of Analytical Chemistry, Faculty of Chemistry, University of Kashan, Kashan, I.R. Iran. ,
Issue Information
فصلنامه با شماره پیاپی 0 سال 2016
Pages
4
From page
86
To page
89
Abstract
در اين مقاله نانوذرات مزوپروس سيليكا سنتز و جهت اتصال ايبوپروفن به آن، با 3-آمينوپروپيل تري اتوكسي سيلان عامل دار شد. . نانوساختارسنتز شده با پراش اشعه X ، ميكروسكوپ الكتروني روبشي، اسپكتروسكوپي مادون قرمز و اسپكتروسكوپي UV-Vis بررسي شد. نتايج نشان داد كه با عامل دار كردن ظرفيت بارگذاري دارو افزايش . سرعت رهايش كاهش مي يابد.
Abstract
In this work we synthesized of mesoporous silica nanoparticles and
functionalized with 3-aminopropyltriethoxysilane to improve the loading
and release of ibuprofen bonded to 3-aminopropyltriethoxysilane. sample
were characterized by Fourier transform infrared spectroscopy, Scanning
electron microscopy , X-ray diffraction, and ultraviolet-visible. the Fourier
transform infrared spectroscopy result demonstrate that organic group were
successfully functionalized onto mesoporous silica nanoparticles. Then, we
investigate of the adsorption and release of ibuprofen as a drug delivery
system in simulated body fluid. The result demonstrates that high adsorption
capacity for drug with functionalized sample and slower drug release rate was
achieved.
Journal title
Journal of NanoStructures
Serial Year
2016
Journal title
Journal of NanoStructures
Record number
2395857
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