Author/Authors :
Mobarra، Naser نويسنده Department of Biochemistry, Metabolic Disorders Research Center, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran. Mobarra, Naser , Shanaki، Mehrnoosh نويسنده Department of Laboratory Medicine, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran Shanaki, Mehrnoosh , Ehteram، Hassan نويسنده Department of Pathology and Medical Laboratory Sciences, Kashan University of Medical Sciences. Kashan, Iran , , Nasiri، Hajar نويسنده Urban planning and design department, Design and Architecture Faculty, University Putra Malaysia , , Sahmani، Mehdi نويسنده Department of Clinical Biochemistry and Genetics, Cellular and Molecular Research Centre , , Saeidi، Mohsen نويسنده , , Goudarzi، Mehdi نويسنده Department of Pharmacology and Toxicology, Pharmacy School, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran Goudarzi, Mehdi , Pourkarim، Hoda نويسنده Department of Hematology, Allied Medical School, Tehran University of Medical Sciences, Tehran, Iran Pourkarim, Hoda , Azad، Mehdi نويسنده ,
Abstract :
Iron chelation therapy is used to reduce iron overload development due to its deposition in various organs such as liver and heart after regular transfusion. In this review, different iron chelators implicated in treatment of iron overload in various clinical conditions have been evaluated using more up-to-date studies focusing on these therapeutic agents. Deferoxamine, Deferiprone and Deferasirox are the most important specific US FDA-approved iron chelators. Each of these chelators has their own advantages and disadvantages, various target diseases, levels of deposited iron and clinical symptoms of the afflicted patients which may affect their selection as the best modality. Taken together, in many clinical disorders, choosing a standard chelator does not have an accurate index which requires further clarifications. The aim of this review is to introduce and compare the different iron chelators regarding their advantages and disadvantages, usage dose and specific applications.
