Author/Authors :
Mahboubi، Mohaddese نويسنده Microbiology Group, Medicinal Plants Research Center of Barij Essence, Kashan, IR Iran , , Taghizadeh، Mohsen نويسنده Department of Biochemistry and Nutrition, Kashan University of Medical Sciences, Kashan, Iran , , Talaei، Sayyed Alireza نويسنده Physiology Research Center, Kashan University of Medical Sciences, Kashan, IR Iran , , Takht Firozeh، Sayyed Mehdi نويسنده Physiology Research Center, Kashan University of Medical Sciences, Kashan, IR Iran , , Rashidi، Ali Akbar نويسنده Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran Rashidi, Ali Akbar , Tamtaji، Omid Reza نويسنده Physiology Research Center, Kashan University of Medical Sciences, Kashan, IR Iran ,
Abstract :
Background
Boswellia serrata and Melissa officinalis is traditionally used for its memory enhancing effects.
Objectives
In this study, we evaluated the protective effects of combined form of these extracts on memory improvement of scopolamine treated rats by the Morris water maze method.
Materials and Methods
Two groups (group 1 and 2) of animals were pretreated with combined extracts of B. serrata and M. officinalis (200, 400 mg/Kg body weight) for four weeks and then, 30 minutes before starting the experiment scopolamine was injected (0.1 mg/kg body weight) intraperitoneally to pretreated animals. The control group was the animals that were injected by scopolamine and pre treated with distilled water (group 3). The normal group was treated with distilled water alone (group 4).
Results
For time spent and distance, there was no substantial difference between groups 1, 2 and 4, while they had statistical difference with group 3 (P = 0.001). The spatial memory evaluation showed no significant difference between treated groups and normal group.
Conclusions
Therefore, the combination of the two extracts had the ability to improve memory as its traditional use.
