Author/Authors :
Jahanbin، Arezoo نويسنده Dental Research Center, School of Dentistry,Department of Orthodontics,Mashhad University of Medical Sciences,Mashhad,Iran , , Abtahi، Mostafa نويسنده Dental Material Research Center, School of Dentistry,Department of Orthodontics,Mashhad University of Medical Sciences,Mashhad,Iran , , Namdar، Parastoo نويسنده School of Dentistry,Department of Orthodontics,Mazandaran University of Medical Sciences,Sari,Iran , , Heravi، Farzin نويسنده Dental Research Center, School of Dentistry,Department of Orthodontic,Mashhad University of Medical Sciences,Mashhad,Iran , , Sadeghi، Fatemeh نويسنده Pharmacology School,Department of Pharmaceutics,Mashhad University of Medical Sciences,Mashhad,Iran , , Arab، Hamidreza نويسنده Dental Research Center, School of Dentistry,Department of Periodontics,Mashhad University of Medical Sciences,Mashhad,Iran , , Shafaee، Hooman نويسنده Oral & Maxillofacial Diseases Research Center, School of Dentistry,Department of Orthodontics,Mashhad University of Medical Sciences,Mashhad,Iran ,
Abstract :
Background.This clinical trial evaluated the effect of Simvastatin on space reopening after orthodontic space closure and its effect on the gingival index (GI) and clinical attachment loss (CAL). Methods. 16 females, 25‒40 years old, with spaces between anterior mandibular teeth due to chronic periodontitis were participated in this study. The patients were randomly divided into control and experimental groups. In the experimental group, 1.2% Simvastatin gel and in the control group, 0.9% sodium chloride as a placebo was injected into the pocket depth of the six anterior teeth. The amount of space reopening, GI and CAL were measured.Results.No serious complications were observed during interventions and followup periods. Space reopening was significantly reduced in patients receiving Simvastatin (P < 0.001). Moreover, GI reduction was significantly greater in Simvastatin group compared to the control group (P < 0.001). However, CAL did not demonstrate a significant difference between the groups.Conclusion.Simvastatin may decrease space reopening after orthodontic space closure in human anterior teeth.
