Evaluation of the Relationship between Serum Lipid Profile andOral Lichen Planus

Background and aims. Oral lichen planus (OLP) is an immunologic disorder. A large number of studies have reported that lipid rafts have a key role in receptor signaling of lymphocytes. Here, we explore the potential of lipid rafts as targets for the development of a new class of agents to downmodulate immune responses and treat autoimmune diseases.Materials and methods. The present crosssectional study evaluated 88 patients referring to the Department of Oral Medicine in 3 groups (Group 1: erosive OLP Group 2: nonerosive OLP Group 3: healthy). A total of 3 mL of blood sle was taken from each subject and the serum levels of cholesterol, triglycerides, HDL and LDL were determined. The mean outcomes of each group were compared with each other and analyzed two by two.Results. The results of statistical analyses showed no significant differences in mean HDL and LDL serum levels between the three groups. The results of post hoc LSD test showed that mean serum levels of subjects with erosive and nonerosive lichen planus were higher than those in healthy subjects. In relation to triglyceride serum levels, the mean serum levels of triglycerides were higher in erosive and nonerosive OLP patients compared to healthy subjects.Conclusion. Triglyceride and cholesterol can be considered to have a critical role in the incidence of lichen planus and in its manifestations as predisposing factors.