Title of article :
Toxicological Effects of 30-Day Intake of Malathion on the Male Reproductive System of Wistar Rats
Author/Authors :
Flehi-Slim، I. نويسنده Research Unity of Genetic (02/UR/08-03), Laboratory of Histology and Cytogenetic, Faculty of Medicine, Monastir, Tunisia , , Boughattas، S. نويسنده Department of Environmental and Biological Chemistry, College of Agriculture, Life and Environmental Sciences , , Belaïd-Nouira، Y. نويسنده Research Unity of Genetic (02/UR/08-03), Laboratory of Histology and Cytogenetic, Faculty of Medicine, Monastir, Tunisia , , Sakly، A. نويسنده , , Neffati، F. نويسنده Laboratory of Biochemistry-Toxicology, University Hospital of Monastir, Tunisia , , Najjar، M.F. نويسنده Laboratory of Biochemistry-Toxicology, University Hospital of Monastir, Tunisia , , Haouas، Z. نويسنده Research Unity of Genetic (02/UR/08-03), Laboratory of Histology and Cytogenetic, Faculty of Medicine, Monastir, Tunisia , , Ben Cheikh، H. نويسنده Research Unity of Genetic (02/UR/08-03), Laboratory of Histology and Cytogenetic, Faculty of Medicine, Monastir, Tunisia ,
Issue Information :
فصلنامه با شماره پیاپی 12 سال 2016
Pages :
5
From page :
152
To page :
156
Abstract :
Background: Malathion (MAL) is a choice insecticide in the stored grain in different countries. The aim of the present study is to evaluate toxicological effects of 30-day intake of MAL on the male reproductive system of Wistar rats. Methods: This research was ethically approved by the local authority at Faculty of Medicine, Monastir, Tunisia. Three MAL treated groups received 1 ml corn oil contain-ing 1.3, 13.7, and 137 mg/kg body weight/day, respectively. Body and testes weights, testosterone, Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) levels were measured. Histopathological sections were prepared from testes of animals and stained with hematoxylin and eosin and also Masson trichrome. Statistical analysis was done using SPSS for windows version 10. Results: A meaningful decrease (p < 0.05) in the testes weight of treatment groups was observed compared to the control animals. However, no significant difference (p > 0.05) was found between body weight of control and treatment groups. All the three MAL-treated rats had significantly (p < 0.05) lower plasma FSH, LH, and testosterone levels than the control group. Some major histopathological changes were found in testes sec-tions of treatment groups. Conclusion: Our study revealed that subchronic and relatively short time exposure of male Wistar rats to MAL can induce histopathological changes in testes and disturbance in sex hormones levels in a dose-dependent manner.
Journal title :
Journal of Food Quality and Hazards Control
Serial Year :
2016
Journal title :
Journal of Food Quality and Hazards Control
Record number :
2398562
Link To Document :
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