Inflammatory Biomarker of Peripheral CRP and Analyzing Serum Trace Elements like Zinc, Copper, and Cu to Zn Ratios in Stable Chronic Obstructive Pulmonary Disease: Tehran-Iran

Background: Chronic Obstructive Pulmonary Disease (COPD) is characterized with incomplete airway reversibility by spirometric testing, chronic local airway and systemic inflammation. COPD is the most common lung disease related to smoking habit in general population. Oxidative stress (Os) is the key mechanism in inducing and progression of inflammatory productions in COPD pathogenesis. However, CRP is a peripheral biomarker to reflect systemic inflammation and tissue damage. Nutritional trace elements like Zinc (Zn) and Copper (Cu) are components of Os mechanism and as the anti-oxidant elements. Those changing serum levels influence on the reaction of recent process and production of inflammatory protein. Propose of the study was to evaluate status of CRP and Zn, Cu, Cu/Zn ratios among male patients with stable Chronic Obstructive Pulmonary Disease. Method: Stable COPD patients substantially were enrolled from pulmonary chest medicine. Applying criteria followed an instruction of thoracic society. Results: A total of 35 patients completed criteria of study. Mean age±SD was 52.8±5years (ranged 43-60). Hypozincemia and hypocupremia were found 11% and 14%, respectively. Conclusion: Increased CRP levels reflected presence systemic and pulmonary inflammation among stable COPD patients. In addition, Zinc and copper deficiency detected among target population. The current trace elements are a part of oxidative stress, and their deficiencies may be effective in the induction of inflammation.