Author/Authors :
Norouzi، A نويسنده Arak University of Medical Sciences, Arak, Iran , , Rajabi ، R نويسنده Arak University of Medical Sciences, Arak, Iran , , Rajabalipour ، F نويسنده Arak University of Medical Sciences, Arak, Iran , , Solhi ، H نويسنده Clinical Toxicologist, Arak University of Medical Sciences, Arak, Iran , , Alimoradian ، A نويسنده Arak University of Medical Sciences, Arak, Iran ,
Abstract :
Background: GI decontamination is required frequently in
management of intoxicated patients. Activated charcoal is used
for this purpose normally. Is it possible that powdered
industrial charcoal is used as a substitute? Present study was
conducted to determine efficiency of industrial charcoal in
prevention of absorption of diazepam, compared to activated
charcoal.
Method: 30 Sprague–dawley rats were randomly divided into
3 equal groups. 20 mg/kg diazepam was given orally to all 3
groups. No GI decontamination was performed for the control
group. Activated and industrial charcoal (1 g/kg dissolved in
10 ml of water) was administered for other two groups. The
urinary concentration of diazepam was used for evaluation of
level of the drug absorption in the animals.
Results: The mean urine concentration of diazepam was
considerably lower in groups taking charcoal, compared
control group. However the concentration in the group taking
activated charcoal was lower than the concentration in the
group taking industrial charcoal.
Conclusion: Results of present study suggest that industrial
charcoal can be used as a substitute for activated charcoal,
though with a little lower efficacy for absorption of drugs and
toxins.
