The Association of DRD2 Gene TaqI Polymorphism with Attention Deficit Hyperactivity Disorder a Population Sample of Iranian Azeri-children

Background Attention deficit hyperactivity disorder (ADHD) is a multifactorial disorder that has defined by hyperactivity, impulsivity and attention deficits. Various neurotransmitters such as dopamine can play a role in its pathophysiology. The aim of this study was to examine the association of two common single nucleotide polymorphisms in DRD2 gene, Taq I A (T/C) and Taq I B (G/A), with ADHA risk among IranianAzeri population. Materials and Methods A study of case–control association was performed with 89 sles with attention deficit hyperactivity disorder and 96 healthy subjects. Peripheral blood sles were used for Genomic DNA extraction by saltingout method. SNP genotyping was carried out by PCRRFLP technique. The collected data were analyzed through javastant online statistics software, using Chisquare, with a significance level of 0.05. Results There was not a significant difference in the allele and genotype frequencies between ADHD and Taq1B polymorphism in cases and controls (P>0.05). In the Taq IA of DRD2 gene, TT homozygous dominants and CC homozygous recessives were more frequent in case group than in control group but significant difference was not observed (P>0.05). Also, T/C heterozygotes were more frequent among the control group than the case group, and difference was significant (P<0.05).