Naltrexone Induced Serotonin Syndrome

Background: Serotonin syndrome resulted from hyperactivity of serotonin in nervous system and is potentially life threatening. Tramadol is known as one itʹs causing factors. Administration of Naltrexone is associated with a significant increase in the ratio of 5-HIAA/5-HT and DOPAC/DA in the frontal cortex and dorsal hippocampus respectively. We present a rare case with some signs of serotonin syndrome and withdrawal syndrome which simultaneously use naltrexone, tramadol and benzodiazepine in the realm of opium addiction. Case Report: A 41 years old man who was admitted due to loss of consciousness and seizure. In simultaneous usage of naltrexone, tramadol and benzodiazepine in an addicted person, and in the case of sever agitation which was resistance to routine treatments, serotonin syndrome beside withdrawal syndrome should be considered and its treatment should be done as soon as possible. Conclusion: In simultaneous usage of naltrexone, tramadol and benzodiazepine in an addicted person, and in the case of sever agitation which was resistance to routine treatments, serotonin syndrome beside withdrawal syndrome should be considered and its treatment should be done as soon as possible.