Author/Authors :
Rekha ، G نويسنده Research Scholar, Department of Anatomy, VMKV Medical College, Salem, Tamil Nadu, India , , Murali ، N نويسنده Department of Animal Genetics and Breeding, Veterinary College and Research Institute, Namakkal, , , Geetha ، T نويسنده VMKV Medical College, Salem, Tamil Nadu, India , , Deepthi ، S نويسنده Department of Anatomy, VMKV Medical College, Salem, Tamil Nadu, India , , Panneer Selvi، G نويسنده Department of Anatomy, VMKV Medical College, Salem, Tamil Nadu, India , , Senthil Kumar ، B نويسنده Department of Anatomy, VMKV Medical College, Salem, Tamil Nadu, India , , Anitha، M.R نويسنده Assistant Professor, Department of Anatomy, S.S.Institute of Medical Sciences & Research center, Davangere, Karnataka (India) ,
Abstract :
Background: Premature Centromere Division (PCD) was
observed in the chromosomes of metaphase spreads in a patient
with the history of recurrent abortions.
Case Report: Short term leukocyte cultures were set up with
blood sample from the woman with a history of recurrent
abortions for the past four consequent years. 25 % of the
metaphase spreads screened displayed premature centromere
division of the chromosomes in each of the cells.
Conclusion: This abnormal behavior of the centromeres may
predispose the individual to cell division errors due to
chromosome instability and the consequences of which may be
a spontaneous abortion.
