Author/Authors :
Farzaneh، Farah نويسنده Infertility and Reproductive Health Research Center, Department of Obstetrics and Gynecology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Farzaneh, Farah , Vahedpour، Zahra نويسنده Department of Obstetrics and Gynecology, Kashan University
of Medical Sciences, Kashan, IR Iran , , Ashrafganjoei، Tahereh نويسنده Department of Obstetrics and Gynecology, Imam Hussein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran , , Rafizadeh، Mitra نويسنده Department of Infectious Diseases and Tropical Medicine , , Ale Bouyeh، Hajar نويسنده Department of Obstetrics and Gynecology, Imam Hossein
Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IR
Iran , , Hosseini، Maryamsadat نويسنده Obstetrics and Gynecology Dept, Imam Hossein Hospital, Shahid Beheshti university (M.C),Tehran, Iran. ,
Abstract :
Background Most gestational trophoblastic neoplasias (GTN) develop
following hydatidiform mole; but may occur after abortion, normal
pregnancy or even ectopic pregnancy. Objectives The aim of this study
was to assess the importance of six-month follow-up of uncomplicated
molar pregnancy after achieving undetectable β-human chorionic
gonadotropin (β-hCG) levels. Patients and Methods In this retrospective
study, molar pregnancies with negative β-hCG were compared with those
with positive β-hCG during a six-month follow-up. Results A total of 279
women with molar pregnancy, treated at two referral university hospitals
in Tehran were analyzed and 86 patients (31%) who had completed their
follow-up period were included. Of the evaluated patients (n = 86), the
pathology report indicated complete mole for 66 patients (77%) and
partial mole for 20 patients (23%). All 86 patients had achieved at
least one undetectable β-hCG level during their follow up, and none
showed evidence of relapse. Conclusions We found that in patients with
uncomplicated molar pregnancy, relapse is unlikely after achieving
undetectable serum β-hCG levels. Further investigations with larger
sample sizes and preferably prospective design are needed to make a
definite conclusion.
