Author/Authors :
Babaknejad ، Nasim نويسنده Department of Biochemistry, Falavarjan Branch, Islamic Azad University, Isfahan, Iran. , , Sayehmiri، Fatemeh نويسنده The Student Research Committee, Ilam University of Medical Sciences, Ilam, Iran , , Sayehmiri، Kourosh نويسنده Department of Social Medicine, Prevention of Psychosocial Injuries Research Centre, Ilam University of Medical Sciences, Ilam, Iran Sayehmiri, Kourosh , Mohamadkhani، Ashraf نويسنده Digestive Disease Research Centre, Shariati Hospital, Tehran University of Medical Science, Tehran, Iran , , BAHRAMI، Somaye نويسنده Research Committee, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran. ,
Abstract :
Abstract
Objective
Autism is a complex behaviorally defined disorder. There is a relationship between zinc (Zn) levels in autistic patients and development of pathogenesis, but the conclusion is not permanent.
Materials & Methods
The present study conducted to estimate this probability using meta-analysis method. In this study, Fixed Effect Model, twelve articles published from 1978 to 2012 were selected by searching Google scholar, PubMed, ISI Web of Science, and Scopus and information were analyzed. I² statistics were calculated to examine heterogeneity. The information was analyzed using R and STATA Ver. 12.2.
Results
There was no significant statistical difference between hair, nail, and teeth Zn levels between controls and autistic patients: -0.471 [95% confidence interval (95% CI): -1.172 to 0.231]. There was significant statistical difference between plasma Zn concentration and autistic patients besides healthy controls: -0.253 (95% CI: 0.498 to -0.007). Using a Random Effect Model, the overall Integration of data from the two groups was -0.414 (95% CI: -0.878 to -0.051).
Conclusion
Based on sensitivity analysis, zinc supplements can be used for the nutritional therapy for autistic patients.
