Title of article
Novel Levofloxacin Derivatives as Potent Antibacterial Agents
Author/Authors
Moshafi، M. H. نويسنده 3Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran , , Bahador، N. نويسنده 1Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutics Research Center, Kerman University of Medical Sciences, Kerman, Islamic Republic of Iran Bahador, N. , Moghimi، S. نويسنده , , Ejtemaei، R. نويسنده 2Drug Design and Development Research Center, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran Ejtemaei, R. , Foroumadi، A. نويسنده Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, I.R.Iran. , , Asadipour، A. نويسنده Kerman Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, I.R.Iran. ,
Issue Information
فصلنامه با شماره پیاپی 0 سال 2017
Pages
5
From page
127
To page
131
Abstract
In this report, a new series of fluoroquinolone agents which was derived from levofloxacin was synthesized and evaluated against Gram-positive (Bacillus subtillis, Staphylococcus aureus, Staphylococcus epidermidis and Micrococcus luteus) and Gram-negative (Esherichio coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and Serratia marcescens) organisms. The results showed that some of the synthesized compounds are strong antibacterial agents. All the synthesized compounds showed remarkable activities against Staphylococcus epidermidis and Staphylococcus aureus (MIC = 0.03-1 µg/mL and 0.06-1 µg/mL respectively).
Journal title
Journal of Sciences
Serial Year
2017
Journal title
Journal of Sciences
Record number
2399400
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