Author/Authors :
Khosravi، Nastaran نويسنده Pediatric Transplantation and Dialysis Research Center, Iran University of Medical Sciences, Tehran, IR Iran , , Abolhasan Choobdar، Farhad نويسنده H. Aliasghar Hospital, Iran University of Medical Sciences, Tehran, IR Iran , , Khalesi، Nasrin نويسنده Pediatric Transplantation and Dialysis Research Center, Iran University of Medical Sciences, Tehran, IR Iran , , Bordbar، Arash نويسنده H. Aliasghar Hospital, Iran University of Medical Sciences, Tehran, IR Iran , , Larijani، Bagher نويسنده , , Arab، Zahra نويسنده , , Nourbakhsh، Mitra نويسنده Metabolic Disorders Research Center, Endocrinology and Metabolism Molecular - Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. Nourbakhsh, Mitra
Abstract :
Ghrelin is a pleiotropic hormone that regulates feeding and energy balance and stimulates growth hormone release. Ghrelin also exerts developmental and organizational effects during prenatal life. The aim of this study was to determine ghrelin levels in cord blood of small for gestational age (SGA) infants and its association with GH (growth hormone) and IGF-1 levels (insulin-like growth factor-1). Cord blood sample was obtained from 31 SGA and 25 appropriate for gestational age (AGA) infants. Acylated ghrelin, GH, and IGF-1 levels were measured by enzyme-linked immunosorbent assay. No significant differences were observed in ghrelin and GH concentrations between SGA and AGA infants. However, IGF-1 levels were significantly lower in SGA infants. Cord blood ghrelin was negatively correlated with the infants’ birth weight (r = -0.33, P = 0.013); on the other hand, IGF-1 level was positively correlated with birth weight (r = 0.43, P = 0.002). IGF-1 has the most significant effect on intrauterine growth. Acylated ghrelin is detectable in cord blood and correlated with birth weight, suggesting a role in intrauterine development, but its level is not affected by intrauterine growth retardation.
