Author/Authors :
Ostadrahimi، Alireza نويسنده Nutrition Research Center, Department of Nutrition, Faculty of Health and Nutrition, Tabriz University of Medical Sciences , , Mohammad-Alizadeh، Sakineh نويسنده Department of Midwifery, Faculty of Nursing and Midwifery,
Research Center of Social Determinants of Health, Tabriz University
of Medical Sciences, Tabriz, IR Iran , , Mirgafourvand، Mozhgan نويسنده Department of Midwifery, Faculty of Nursing and Midwifery,
Tabriz University of Medical Sciences, Tabriz, IR
Iran , , Yaghoubi، Sina نويسنده Medical Education Research Center, Tabriz University of Medical Sciences, Tabriz, Iran , , Shahrisa، Elham نويسنده Health Center, Tabriz University of Medical Sciences,
Tabriz , IR Iran , , Farshbaf-Khalili، Azizeh نويسنده MSc, Department of Midwifery, Faculty of Nursing and Midwifery, Tabriz University of Medical Sciences, Tabriz, Iran Farshbaf-Khalili, Azizeh
Abstract :
One of the most common complications of pregnancy is gestational
diabetes mellitus (GDM), which is increasing worldwide. Experimental and
epidemiological studies have shown that higher intake of n-3 long-chain
polyunsaturated fatty acids may decrease the risk of various diseases
such as diabetes. The objective of this study was to assess the effect
of fish oil supplementation on the prevention and treatment of GDM. This
systematic review was performed by searching several databases,
including PubMed, Scopus, Google Scholar, the Cochrane Library,
ProQuest, Science Direct SID, Magiran and IranMedex since 1983. The
researchers also searched for references in reviewed clinical trial
articles in which fish oil supplementation was compared with placebo or
no supplementation. Only two published and in-press articles are
included in this review. Based on these studies, docosahexaenoic acid
(DHA)-enriched fish oil (800 mg/d) had no effect on prevention of GDM
[0.97 (95% CI: 0.74, 1.27)]. Furthermore, omega-3 fatty acid
supplementation containing 180 mg of eicosapentaenoic acid (EPA) and 120
mg DHA had beneficial effects on insulin resistance in women with GDM
(change from baseline: 1.5 ± 7.5 vs 3.5 ± 8.5 mIU/mL, P = 0.02) but did
not influence fasting plasma glucose, homeostatic model assessment-Beta
cell function (HOMA-B), the quantitative insulin sensitivity check index
(QUICKI), or lipid profiles (P > 0.05). There is not enough
evidence to support or refute the routine use of fish oil supplements
during pregnancy for the prevention or treatment of diabetes. It is
suggested that further randomized controlled trials be conducted to
evaluate the role of fish oil supplementation in pregnancy.
