Author/Authors :
Mohammadi Ziarani، Ghodsi نويسنده Department of Chemistry, Alzahra University, Tehran, Iran , , Ghorbi، Shima نويسنده Department of Chemistry,Alzahra University,Tehran,Iran , , Gholamzadeh، Parisa نويسنده Department of Chemistry,Alzahra University,Tehran,Iran , , Badiei، Alireza نويسنده School of Chemistry, College of Science,University of Tehran,Tehran,Iran ,
Abstract :
Sulfonic acid functionalized nanoporous silica (SBA-Pr-SO3H) with a pore size of 6 nm catalyzed three component coupling of aromatic aldehydes, urea and ethyl acetoacetate to afford the corresponding dihydropyrimidinones under solvent free conditions. This new protocol for the Biginelli reaction has important advantages such as green synthesis, short reaction time, high yields of the products and easy isolation and reusability of the catalyst. SBA-Pr-SO3H was proved to be an efficient heterogeneous nanoporous solid acid catalyst which could be easily handled and removed from the reaction mixture by simple filtration and can be recovered and reused for several times without any loss of activity.
Keywords :
Dihydropyrimidinone , Biginelli reaction , SBA-Pr-SO3H , Green synthesis
