Author/Authors :
Kawade، Deepak S. نويسنده Department of Chemistry,Dr. Babasaheb Ambedkar Marathwada University,Aurangabad,India , , Chaudhari، Mahendra A. نويسنده Department of Chemistry,Dr. Babasaheb Ambedkar Marathwada University,Aurangabad,India , , Gujar، Jitendra B. نويسنده Department of Chemistry,Dr. Babasaheb Ambedkar Marathwada University,Aurangabad,India , , Shingare، Murlidhar S. نويسنده Department of Chemistry,Dr. Babasaheb Ambedkar Marthwada University,Aurangabad,India ,
Abstract :
Herein we explore facile synthesis of 4-(3H)-Qunazolinone derivatives, achieved by the cyclocondensation of anthranilic acid, aromatic amines and triethyl orthoformate in presence of thiamine hydrochloride (Vitamin B1) as a catalyst, using grinding method. This protocol offers several advantages such as reusability of catalyst, excellent yield, shorter reaction time and economic availability.
Keywords :
anthranilic acid , Multi-component reaction , Thiamine hydrochloride (Vitamin B1) , 4-(3H)-Quinazolinones
