Author/Authors :
Kalam Khan، Firoz A. نويسنده Y.B. Chavan College of Pharmacy, Dr. Rafiq Zakaria Campus,Aurangabad,India , , Pachpinde، Amol M. نويسنده Department of Chemistry,awahar Art Science and Commerce College,Osmanabad,India , , Langade، Mallinath M. نويسنده Department of Chemistry,Jawahar Art Science and Commerce College,Osmanabad,India , , Lohar، Kishan S. نويسنده Materials Research Laboratory,Srikrishna Mahavidyalaya Gunjoti,Omerga,India , , Patange، Sunil M. نويسنده Materials Research Laboratory,Srikrishna Mahavidyalaya Gunjoti,Omerga,India , , Bhusnure، Omprakash G. نويسنده Department of Quality Assurance,Channabasweshwar Pharmacy College,Latur,India , , Sangshetti، Jaiprakash N. نويسنده Y.B. Chavan College of Pharmacy, Dr. Rafiq Zakaria Campus,Aurangabad,India ,
Abstract :
A facile and highly efficient onepot synthesis of multisubstituted pyrrole derivatives is reported via a fourcomponent reaction of amines, aldehydes, acetylacetone and nitromethane using Pr3+ doped CoFe2O4 as a catalyst in solvent free conditions at 90°C. The catalyst is easily recoverable using magnet and could be reused without a significant loss of catalytic activity. Even after five runs for the reaction, the catalytic activity of Pr3+ doped CoFe2O4 was almost the same as that of the freshly used catalyst. The proposed method is advantageous due to its little catalyst loading, short reaction time, catalyst reusability, and excellent yields.
