Author/Authors :
Karbalaie، Khadijeh نويسنده Faculty of science,Department of Biology, Division of Genetics,University of Isfahan,Isfahan,Iran , , Vallian، Sadeq نويسنده Faculty of science,Department of Biology, Division of Genetics,University of Isfahan,Isfahan,Iran , , Lachinani، Liana نويسنده Cell Science Research Center, Royan Institute for Biotechnology,Department of Cell and Molecular Biology,Academic Center for Education, Culture & Research (ACECR),Isfahan,Iran , , Nasr-Esfahani، Mohammad Hossein نويسنده Cell Science Research Center, Royan Institute for Biotechnology,Department of Cellular Biotechnology,Academic Center for Education, Culture & Research (ACECR),Isfahan,Iran ,
Abstract :
PML (Promyelotic Leukemia) protein is a tumor suppressor protein encoded by the PML gene. This protein is known as one of the main components of PML nuclear bodies (PMLNBs) in the nucleolus. The number and morphology of these structures vary in different cells. Due to alternative splicing, posttranslational modifications, and interactions with different partners, this protein has acquired different localizations and functions in the cell. Most studies have focused on the role of this protein in tumor suppression and myeloid differentiation. In this article, we review the role of this protein in cellular activity, and its importance in stem cell characteristics and neural development.
Keywords :
Cell differentiation , Tumor suppressor , Pluripotency , Promyelotic Leukemia , PML Nuclear Bodies , gene
