Author/Authors :
Naderi، Majid نويسنده Ali Ebn-e-Abitaleb Hospital, Research Center for Children and Adolescents Health [RCCAH],Department of Pediatrics Hematology & Oncology,Zahedan University of Medical Sciences,Zahedan,Iran , , Tabibian، Shadi نويسنده Allied Medical School,Department of Hematology and Blood Transfusion,Tehran University of Medical Sciences,Tehran,Iran , , Alizadeh، Shaban نويسنده Allied Medical School,Department of Hematology and Blood Transfusion,Tehran University of Medical Sciences,Tehran,Iran , , Abtahi، Zahra Sadat نويسنده Allied Medical School,Department of Hematology and Blood Transfusion,Tehran University of Medical Sciences,Tehran,Iran , , Dorgalaleh، Akbar نويسنده Allied Medical School,Department of Hematology and Blood Transfusion,Iran University of Medical Sciences,Tehran,Iran ,
Abstract :
Factor XIII (FXIII) is a heterotetramer consisting of two subunits, FXIII-A and FXIII-B. Several common gene variations were observed in FXIII-A gene with obvious ethnic difference. This study assessed prevalence of A614T as a common FXIII-A gene variation among Iranian patients with FXIII deficiency (FXIIID). Materials and Methods: This study was conducted on eighty Iranian unrelated individuals with FXIIID. Genotype analysis for FXIII-A A614T gene variation was performed for all individuals. Results: Molecular analysis of these Iranian populations revealed that all studied patients were homozygous for T allele at codon 204 of FXIII-A1 subunit. Conclusion: Present of T allele at codon 204 of FXIII-A1 subunit among all study population can be suggestive of founder effect.
