Author/Authors :
Payani، Narges نويسنده Anesthesiology Research Center,Shahid Beheshti University of Medical Sciences,Tehran,Iran , , Foroughi، Mahnoush نويسنده Cardiovascular Research Center,Shahid Beheshti University of Medical Sciences,Tehran,Iran , , Bagheri، Abdolhamid نويسنده Cardiovascular Research Center,Shahid Beheshti University of Medical Sciences,Tehran,Iran , , Rajaei، Samira نويسنده School of Medicine,Immunology Department,Tehran University of Medical Sciences,Tehran,Iran , , Dabbagh، Ali نويسنده Professor, Fellowship in Cardiac Anesthesiology, Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran ,
Abstract :
There are always concerns regarding postoperative bleeding in coronary artery bypass graft (CABG) patients; a number of different strategies have been used to compensate for it and to reduce the amount of blood transfusion. We designed this study to investigate local fibrinogen condition in postoperative bleeding in adult patients undergoing CABG.
Materials and Methods: In a double blind clinical trial, after matching the inclusion and exclusion criteria, 50 patients entered the study. Pre- and postoperative data, including clinical and laboratory variables were assessed. Among them, pre- and postoperative fibrinogen levels were measured. One group received 1g fibrinogen as 50mL solution flushed over the epicardium before sternal closure; the other received 50mL normal saline as placebo in the same method.
Results: No difference between the two groups regarding preoperative and postoperative fibrinogen levels. Also, two groups were the same regarding PT, PTT, INR and platelet. However, bleeding was less and hematocrit level was higher in local fibrinogen group. Conclusion: Local fibrinogen could decrease postoperative bleeding in CABG patients leading to decreased need for blood transfusion.
