Title of article :
Zinc Chloride Reverse Influence on Dexamethasone Depressant Effects in Adult Male Rats
Author/Authors :
Navabi، Seyedeh Parisa نويسنده Department of Biology, Faculty of Science, Shahid Chamran University, Ahvaz, IR Iran , , Eshagh Harooni، Hooman نويسنده Department of Biology, Faculty of Sciences, Shahid Chamran University, Ahvaz, Iran , , Moazedi، Ahmad Ali نويسنده Biology Department, Faculty of Sciences, Shahid Chamran University of Ahwaz, Ahwaz, Iran , , Khajehpour، Lotfolah نويسنده Department of Biology, Faculty of Science, Shahid Chamran University, Ahvaz, Iran. ,
Issue Information :
فصلنامه با شماره پیاپی 26 سال 2015
Pages :
6
From page :
1
To page :
6
Abstract :
Background: Cumulative evidence shows that dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis is involved in the depressive disorders and natural or synthetic glucocorticoids have a direct effect on HPA activity. Objectives: Considering the reports that show zinc deficiency is one of the causes of depressive-like behavior, the current study aimed to examine the effects of systemic injection of zinc chloride (ZnCl2) and/or dexamethasone sodium-phosphate (DEX) on depression in adult male rats. Materials and Methods: Different groups received ZnCl2 (2.5, 5, 10, and 20 mg/kg) and DEX (0.5, 1, 5, 10, and 30 mg/kg) and then depression was assessed in the forced swimming test (FST). Results: Results showed that DEX 1 significantly increased, while DEX 30 and groups treated with zinc 10 mg/kg and zinc 20 mg/kg decreased total immobility time as compared to that of saline group. Also there was a significant decrease of total immobility time when zinc administered to rats already received DEX 1, compared with that of control group. Conclusions: The current study findings suggest that zinc has antidepressant effects dose dependently, while administration of DEX induced dual effects on depression; therefore, a low dose of DEX showed an increased level of depressive-like behavior while higher doses had antidepressant effects. Also, results showed that zinc administration could ameliorate depressive-like behavior induced via dexamethasone in FST.
Journal title :
Astroparticle Physics
Serial Year :
2015
Record number :
2401658
Link To Document :
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