Author/Authors :
Zanganeh ، Shima نويسنده MSc Student of Clinical Biochemistry, Dept. of Clinical Biochemistry, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran Zanganeh , Shima , Roostaei ، Farzad نويسنده MSc Student of Clinical Biochemistry, Dept. of Clinical Biochemistry, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. Roostaei , Farzad , Shafiepour ، Mohammad Reza نويسنده Assistant Prof., of Internal medicine, Dept. of Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. Shafiepour , Mohammad Reza , Mahmoodi، Mehdi نويسنده , , Khoshdel، Ali Reza نويسنده , , Hajizadeh، Mohammad Reza نويسنده Department of Biochemistry, Rafsanjan University of Medical Sciences, Rafsanjan, Iran; ,
Abstract :
Background: Chemerin is and adipokine produced and secreted by adipose tissue and is associated with functions such as insulin resistance, inflammation, and blood pressure regulation. The purpose of the present study was the determination of serum chemerin level in an Iranian population with metabolic syndrome and its comparison with healthy individuals.
Materials and Methods: The study subjects consisted of 31 individuals with metabolic syndrome and 25 healthy individuals (control group). Serum chemerin level was measured and its relationship with indices of metabolic syndrome, obesity, and insulin resistance was determined. The collected data were analyzed using independent two-sample t-test and the Pearson correlation coefficient in SPSS software.
Results: Serum chemerin level was significantly higher in the metabolic syndrome group compared to the control group (P = 0.009). The mean of the measured indices of BMI (P < 0.001), waist circumference (P < 0.001), systolic blood pressure (P = 0.001), diastolic blood pressure (P < 0.001), insulin resistance (P = 0.001), and triglyceride (P < 0.001) was significantly higher in the metabolic syndrome group compared to the control group. However, HDL level was significantly higher in the control group compared to the metabolic syndrome group (P = 0.007).
Conclusions: Serum chemerin level was higher among patients with metabolic syndrome compared to healthy individuals. Thus, it can be concluded that serum chemerin level measurement can be effective in the diagnosis of this syndrome and determination of appropriate treatment methods.
