Author/Authors :
TONEKABONI، Seyed Hasan نويسنده 5. Professor of Pediatric Neurology, Pediatric Research Center, Shahid Beheshti University of Medical Sciences (SBMU), Tehran, Iran , , JAFARI، Narjes نويسنده Pediatric Neurology Department, Mofid Children Hospital, Faculty of Medicin, Shahid Beheshti University of Medical Sciences, Tehran, Iran , , MANSOURI، MAHBOUBEH نويسنده , , Jabbehdari، Sayena نويسنده Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Disease (NRITLD) , , EFTEKHARI، Rahil نويسنده Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran , , Chavoshzadeh، Zahra نويسنده , , Abdollah Gorji، Fatemeh نويسنده , , Mesdaghi، Mehrnaz نويسنده Pediatric Infections Research Center, Shahid Beheshti University of Medical Sciences ,
Abstract :
Abstract
Objective
Anticonvulsant drugs can cause various forms of skin drug reactions, ranging from exanthema to severe blistering reactions. An association between HLA-B*1502 allele and severe skin reactions have been reported.
Materials & Methods
Fifteen patients with severe skin reactions following treatment with anticonvulsant drugs (Carbamazepine, lamotrigine, phenobarbital, primidone) and 15 controls (age-matched epileptic patients taking similar anticonvulsants without drug eruption) were included. They were referred to Mofid Children’s Hospital in Tehran, Iran, between Jan 2012 to Jan 2014. Genomic DNA was extracted from peripheral blood of all patients and HLA- B*1502 genotype was detected by real-time PCR.
Results
None of the patients was positive for HLA- B*1502, but two patients in control group had positive HLA- B*1502.
Conclusion
The HLA- B*1502 is not correlated with severe anticonvulsant drugs -induced skin reactions in Iranian children.
