Comparison between Fluconazole and Terbinafine in the treatment of Tinea corporis and Tinea cruris

Objectives: This study aimed to compare the therapeutic efficacy of Terbinafine and Fluconazole in terms of mycological cure in the treatment of Tinea corporis and Tinea cruris. Method: In this clinical trial, 30 patients with T. corporis and T .cruris were selected. Patients were divided into two groups by random selection. The first group was treated with Fluconazole 150 mg weekly for four weeks and the second group was administered Terbinafine 250 mg daily for two weeks. The participants were followed up till the end of the treatment and one month after treatment. Results: At the end of the treatment, 64.3% of the subjects in Fluconazole group developed clinical and laboratory responses; while the second group developed 75% clinical and 81.3% laboratory cure. One month later, 64.3% in the Fluconazole group were cured, while in the other group, 87.5% were cured. No patient had any side effect. Conclusion: Although, no significant difference was observed between these two groups of patients in clinical and laboratory aspect, as a result of lower price and easier consumption, it is suggested that Fluconazole is more suitable for treatment of Tinea infections.