Author/Authors :
Zibaei، Mohammad نويسنده 1Department of Parasitology and Mycology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran , , Salehi، Sepideh نويسنده 2Department of Biology, Arak Branch, Islamic Azad University, Arak, Iran , , Jafari، Zohreh نويسنده 2Department of Biology, Arak Branch, Islamic Azad University, Arak, Iran , , Bahadory، Saeed نويسنده Department of Parasitology and Mycology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran , , Firoozeh، Farzaneh نويسنده 3Department of Microbiology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran , , Shahivand، Mehdi نويسنده 2Department of Biology, Arak Branch, Islamic Azad University, Arak, Iran ,
Abstract :
Background: The basic approaches for the treatment of human hydatidosis are surgery and chemotherapy. The risk of spillage of protoscoleces cannot be underestimated during surgery.
Objectives: This study aimed to evaluate the scolicidal activity of Ephedra major methanol extracts against protoscoleces of hydatid cysts.
Materials and Methods: Various concentrations of the methanolic extracts (0.01%-0.001%, mg/mL) of different parts of E. major were used for exposure times of 10, 20, 30, and 60 minutes.
Results: Different extracts of E. major were tested, 0.1% concentration had strong scolicidal activity in 60 minutes. The stem extracts of 0.1% had very strong scolicidal effects in 60 minutes of exposure time and the mortality rate decreased with the lower concentration.
Conclusion: Findings showed that scolicidal effects of E. major root extracts against cystic echinococcosis protoscoleces were less effective, while the stem and leaf extracts demonstrated more activities, respectively.
