Author/Authors :
تي. كمبل، وينود نويسنده Organic Chemistry Research laboratory, Department of Chemistry, Institute of Science, Nagpur-440001 Maha-rashtra, India T. Kamble, Vinod , تي. اتكور، سنديپ نويسنده School of Chemical Sciences, Swami Ramanand Teerth Marathwada University, Vishnupuri, Nanded-431606 Ma-harashtra, India T. Atkore, Sandeep , ام. پيسال، پارشورام نويسنده School of Chemical Sciences, Swami Ramanand Teerth Marathwada University, Vishnupuri, Nanded-431606 Ma-harashtra, India M. Pisal, Parshuram , صدف، مونازا نويسنده Organic Chemistry Research laboratory, Department of Chemistry, Institute of Science, Nagpur-440001 Maha-rashtra, India Sadaf, Munazza , وي. تاكر، رنوكا نويسنده Organic Chemistry Research laboratory, Department of Chemistry, Institute of Science, Nagpur-440001 Maha-rashtra, India V. Thakre, Renuka
Abstract :
The highly substituted pyridine derivatives are found to exhibit diverse pharmacological activi-ties. They are also emerged as potential medicinal leads in developing therapeutic agents for the treatment of various diseases. In this work, a series of 2-amino-3,5-dicarbonitrile-6-thio-pyridine derivatives have been synthesized at room temperature via one-pot, multi-component reaction of various aromatic aldehydes, malononitrile and thiophenols using catalytic amount of tetrabu-tylammonium bromide (TBAB) and cesium carbonate in methanol. In the mentioned method, the use of thermal condition is avoided. In addition, the advantages such as operational simplicity, economic viability, ecologically benign nature make this protocol a very efficient alternative to the literature methods.
