Author/Authors :
جعفري ، علي نويسنده Jafari, A , رمضاني، علي نويسنده دانشكده داروسازي,گروه بيوتكنولوژي, دانشگاه علوم پزشكي زنجان,زنجان,ايران , , جو، سانگ وو نويسنده School of Mechanical Engineering, Yeungnam University, Gyeongsan 712-749, Republic of Korea Joo, Sang Woo , احمدي، ياور نويسنده , , صدري، فريبا نويسنده Department of Chemistry, Payame Noor University, P.O. BOX 19395-4697 Tehran, Iran Sadri, Fariba , عظيم زاده آسيابي، پگاه نويسنده - ,
Abstract :
A green and convenient protocol is described for the preparation of 1-(alkylamino)-3-(1,3-dioxoisoindolin-2-yl)-2-methyl-1-oxopropan-2-yl benzoates via one-pot three-component reaction between 2-(2-oxopropyl)isoindoline-1,3-dione, an alkyl isocyanide and an aromatic carboxylic acid in water at room temperature. The methods used to follow the reactions are TLC and NMR, which indicated that there is no side product and the products were obtained without any purification. The structures of the products were deduced from their 1H NMR, 13C NMR and IR spectra. The present methodology offers several advantages such as a simple procedure, catalyst-free, mild reaction conditions, high yields, and the absence of any volatile and hazardous organic solvents.
