Author/Authors :
Mofid، Bahram نويسنده , , Shankayi، Zeinab نويسنده Department of Medical Physics, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran , , Novin، Kambiz نويسنده Clinical Oncology Department, Shahid Beheshti University
of Medical Sciences, Tehran, IR Iran , , Dehghani rokh، Mohammad sadegh نويسنده Electronic Campus, Islamic Azad University, Tehran, Iran , , Shankayi، Morteza نويسنده Department of Mechanic, School of Engineering, Tarbiat Modares University, Tehran, Iran. Shankayi, Morteza , Haghighatkhah، Hamidreza نويسنده , , Firoozabadi، S. Mohammad نويسنده Department of Medical Physics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran Firoozabadi, S. Mohammad
Abstract :
Electrochemotherapy (ECT) is a new local treatment method for solid and superficial tumors. During this new technique, patients experience an unpleasant sensation and slight edema. Most unpleasant and painful is mainly attributed to muscle contractions provoked by high amplitude and low repetition frequency pulses. Recently, we showed that electrochemotherapy using low voltage and higher repetition frequency (LVHF ECT) is an effective tool for inhibiting tumor growth and inducing cell permeabilization. Low voltage high-frequency electrochemotherapy was developed and optimized in vitro and in vivo which and can be used in the clinic. In the present study, we report a case of cervical lymph node metastasis of breast cancer treated by the technique. In our case, LVHF ECT was successful in reducing the size and palliating the symptoms of cervical lymph node metastasis in clinical conditions, whereas other approaches were inefficient. Our electrochemotherapy technique shows good clinical results. However, more studies on this new method are necessary to prove that LVHF ECT can be considered as a standard treatment modality.
