An efficient synthesis of tetrahydrotetrazolo[1,5-a]quinazoline derivatives by a three-component reaction of 5-aminotetrazole, arylaldehydes, and dimedone

A series of tetrahydrotetrazolo[1,5-a]quinazoline derivatives were prepared by the three-component condensation reaction of 5-aminotetrazole (5-AT), benzaldehydes, and dimedone, in the presence of p-toluenesulfonic acid (p-TSA) as a solid acid catalyst, under solvent-free conditions. This protocol provides a simple one-step procedure with the advantages of having easy work-up, mild reaction conditions, and being environmentally benign.