Author/Authors :
Mahmoodi Mehdi نويسنده , Khoshdel Alireza نويسنده , Hassanipour Mahsa نويسنده Department of Pharmacology and Toxicology, Pharmaceutical Sciences Branch and Pharmaceutical Sciences
Research Center, Islamic Azad University, Tehran, Iran. AND Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. AND Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran. Hassanipour Mahsa , Jalali Mitra نويسنده Department of Clinical Biochemistry, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. , Hajizadeh Mohammadreza نويسنده Department of Clinical Biochemistry, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. , Khanamani Falahati Pour Soudeh نويسنده Molecular Medicine Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. , Roustai Farzad نويسنده 1Department of Clinical Biochemistry, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. , Rezai Marzieh نويسنده 1Department of Clinical Biochemistry, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Abstract :
Background and Aims: Metabolic syndrome, a common metabolic disorder, for the serious health consequences such as insulin resistance and lipid abnormalities has been considered as a major clinical challenge with obscure causes. Oxidative stress is an important component of metabolic syndrome, contributing in its development. Troxerutin, a semi-synthetic derivative of natural bioflavonoid rutin, exerts various pharmacological activities, which among all, strong anti-oxidative property is of great importance. The aim of the current study was to evaluate the effects of troxerutin on metabolic parameters and oxidative stress in metabolic syndrome induced by fructose in male rats.
Materials and Methods: In order to induce metabolic syndrome, animals received the water containing 20% fructose for 8 weeks. Troxerutin was administered to animals with the dose of 150 mg/kg orally for 4 weeks after induction of metabolic syndrome following biochemical analysis and oxidative stress marker assessment.
Results: Data showed that high-fructose diet leads to elevation of blood glucose and insulin resistance and causes abnormalities in lipid profile as well as oxidative stress enhancement (signs of a metabolic syndrome) (p < 0.001). Troxerutin administration improved the detrimental effects of metabolic syndrome on biochemical factors and diminished oxidative stress (p < 0.001).
Conclusions: Troxerutin administration reverses the deleterious effect of metabolic syndrome in rats with high-fructose diet.
