Author/Authors :
Motevalizadeh, Farshad Particulate Fluids Processing Centre - School of Chemistry - University of Melbourne, Melbourne, Australia , Khoobi, Mehdi Department of Pharmaceutical Biomaterials and Medical Biomaterials Research Center - Faculty of Pharmacy - Tehran University of Medical Sciences, Tehran, Iran , Babanejad, Niloofar Department of Pure Chemistry, Faculty of Chemistry - Shahid Beheshti University, G.C.Tehran, Iran , Mohit, Elham Department of Pharmaceutical Biotechnology - School of Pharmacy - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Dehghankelishadi, Pouya Department of Pharmaceutical Biomaterials and Medical Biomaterials Research Center - Faculty of Pharmacy - Tehran University of Medical Sciences, Tehran, Iran , Akbari Javar, Hamid Department of Pharmaceutics, Faculty of Pharmacy - Tehran University of Medical Sciences, Tehran, Iran , Dorkoosh, Farid A Department of Pharmaceutical Biomaterials and Medical Biomaterials Research Center - Faculty of Pharmacy - Tehran University of Medical Sciences, Tehran, Iran , Faramarzi, Mohammad Ali Department of Pharmaceutical Biotechnology - Faculty of Pharmacy and Biotechnology Research Center - Tehran University of Medical Sciences, Tehran, Iran , Shafiee, Abbas Department of Medicinal Chemistry - Faculty of Pharmacy and Pharmaceutical Sciences Research Center - Tehran University of Medical Sciences, Tehran, Iran
Abstract :
A multifunctional nanocarrier with multilayer core–shell architecture was prepared by chemical modification of Fe3O4 magnetic nanoparticle (MNPs) with acrolein–styrene–polyethyleneimine (AL–St–PEI) via covalent bonding. MNPs were prepared by co-precipitation method, and then, thiol functionalized (MNPs-SH) were synthesized by treating MNPs with the (3-mercaptopropyl) trimethoxysilane. Subsequently, the copolymerization of St and AL was performed in the presence of the MNPs-SH and butyrolactam by thiol-lactam initiated radical polymerization. Finally, PEI was covalently bounded to the aldehyde groups on the surface of AL–St copolymer. The AL–St–PEI MNPs were investigated by FTIR, XRD, TGA, SEM and TEM. The drug release from AL–St–PEI MNPs was evaluated using doxorubicin as the model anticancer. Furthermore, to determine the effect of drug structure in the release profile from the modified MNPs, some lipophilic model drugs were studied in loading and release study. It was found that the nature of the drugs affect the release profile. The in vitro release modeling demonstrated that doxorubicin release is described by zero-order mechanism while release of lipophilic model drugs is controlled by fickian diffusion.
Keywords :
Acrolein–styrene copolymer , Polyethyleneimine , Superparamagnetic Fe3O4 , Thiol-lactam initiated radical polymerization
