Evaluation of Serum GH, IGF-1, and IGFBP-3 Levels as Biomarkers in The Diagnosis of Acute Myocardial Infarction

This study aimed to determine the role of the serum growth hormone and insulin-like growth factor–binding proteins 3 levels measured in the first 24 h in the diagnosis and pathophysiology of acute myocardial infarction (AMI). The levels of serum Growth hormone, insulin-like growth factors1, and insulin-like growth factor–binding proteins 3 of the patients diagnosed with AMI in the first 24 h of onset and that of the control group at the time of admission were compared between January 1 and August 31, 2010. The average age of the patient group was 59.36 ± 13: 25 years, and 79.4% of the patients were males. The serum growth hormone and insulin-like growth factor–binding proteins 3 levels were significantly higher in the patient group (P < 0.05). However, no differences were found between insulin-like growth factors 1 levels in both the groups (P > 0.05). The sensitivity of growth hormone was 84.1% with a cutoff value of 0.14; the sensitivity of insulin-like growth factors1 was 33.6% with a cutoff value of 162; and the sensitivity of insulin-like growth factor–binding proteins 3 was 75.7% with a cutoff value of 2862. The present study showed that growth hormone and insulin-like growth factor binding proteins 3 markers play important roles in the pathophysiology of myocardial infarction. Hence, it is thought that they can be used in the diagnosis of AMI. Further studies are needed to validate the conclusion.