Author/Authors :
Mahdavi, Mohammad School of Pharmacy - International Campus (TUMS-IC) - Tehran University of Medical Sciences, Tehran , Mohammadi-Izad, Samira School of Pharmacy - International Campus (TUMS-IC) - Tehran University of Medical Sciences,Tehran , Saeedi, Mina Medicinal Plants Research Center - Faculty of Pharmacy - Tehran University of Medical Sciences, Tehran , Safavi, Maliheh Department of Biotechnology - Iranian Research Organization for Science and Technology,Tehran , Sadat Ebrahimi, Esmaeil School of Pharmacy - International Campus (TUMS-IC) - Tehran University of Medical Sciences,Tehran , Foroumadi, Alireza Department of Medicinal Chemistry - Faculty of Pharmacy and Pharmaceutical Sciences Research Center - Tehran University of Medical Sciences,Tehran , Shafiee, Abbas Department of Medicinal Chemistry - Faculty of Pharmacy and Pharmaceutical Sciences Research Center - Tehran University of Medical Sciences,Tehran
Abstract :
This work describes synthesis of novel chromenone derivatives bearing 4-nitrophenoxy phenyl acryloyl moiety through the reaction of 4-(4-nitrophenoxy)benzaldehydes and 3-acetyl-2H-chromen-2-ones in refluxing toluene. Cytotoxicity of all compounds was evaluated using a tetrazolium (MTT) colorimetric assay against human breast cancer cell line, MDA-MB-231.
