Author/Authors :
Nariman Shahin نويسنده , Sepidarkish Mahdi نويسنده , Mosayebi Ziba نويسنده Department of Pediatrics and Neonatology, School of Medicine, Kashan University of Medical Sciences, Kashan, IR Iran , Sagheb Setareh نويسنده Department of Pediatrics, Tehran University of Medical Sciences, Tehran, IR Iran , Nikseresht Zahra نويسنده Faculty of Medicine, Tehran University of Medical
Sciences, Tehran, IR Iran , Sharifi Marzieh نويسنده Faculty of Medicine, Tehran University of Medical
Sciences, Tehran, IR Iran
Abstract :
Background Since the intraventricular hemorrhage (IVH) is still a
serious problem in premature infants associated with poor
neurodevelopmental outcomes, there is a need for an accessible tool in
order to identify these at high risk neonates. Objectives To determine
if high mean platelet volume (MPV) within 24 hours of birth can identify
preterm infants prone to IVH as a simple accessible test. Methods One
hundred premature infants with gestational age (GA) of < 34 weeks
with respiratory distress syndrome (RDS) were eligible in this study and
were divided into two groups based on the diagnosis of IVH. Measurements
of MPV and platelet counts were performed during the first hours of
admission and on the third day of life. Elevated MPV was defined as a
value of ≥ 11 fL. Results Seventy four percent of infants with IVH had
an MPV of more than 11 fL compared to twenty six percent in infants
without IVH (Crude OR: 10.71, 95%CI: 4.26 to 26.90, P < 0.001).
Multivariate logistic regression analysis of selected variables
demonstrated that MPV (Adjusted OR: 10.68, 95%CI: 3.20 to 35.59, P
< 0.001) and GA (Adjusted OR: 0.54, 95%CI: 0.40 to 0.74, P
< 0.001) were related to the occurrence of IVH. Conclusions High
MPV within 24 hours of birth can be determined as a simple available
laboratory test for identifying NICU-admitted premature infants at risk
of IVH.
