Author/Authors :
Zhang Wenjuan نويسنده Weinan Vocation and Technical College, Weinan, Shaanxi Province, 714026, P. R. China , Ma Saijian نويسنده Microbiology Institute of Shaanxi, 76 Xiying Rd, Xi’an, Shaanxi Province, 710043, P. R. China , An Chao نويسنده Microbiology Institute of Shaanxi, 76 Xiying Rd, Xi’an, Shaanxi Province, 710043, P. R. China , Xue Wenjiao نويسنده Microbiology Institute of Shaanxi, 76 Xiying Rd, Xi’an, Shaanxi Province, 710043, P. R. China
Abstract :
[Background]Microorganisms represent a potentially valuable source of biologically significant compounds that should be explored for their potential agrochemical use.[Objectives]The compounds ZM-1 and ZM-2 were isolated from the extract of the fermentation broth of Streptomyces parvus 33 by bioassay-guided fractionation.[Methods]The compound ZM-1 was isolated in the form of a clear single crystal for the first time, and identified as holomycin via X-ray crystallography. The compound ZM-2 was characterized by IR, 1H-NMR, 13C-NMR, DEPT (90° and 135°), and MS analyses.[Results]The compound ZM-1 showed a strong antibacterial activity against the tested bacteria, and its value of minimum inhibitory concentration (MIC) was greater than that of the positive control Ampicillin. The compound ZM-1 also exhibited significant antimicrobial activities against some plant pathogenic fungi. Nevertheless, ZM-2 showed no activities against the tested bacteria and plant pathogenic fungi.[Conclusions]The compound ZM-1 was isolated in the form of a clear single crystal for the first time, and identified as holomycin via X-ray crystallography. Streptomyces parvus 33 is a newly discovered producer of holomycin. ZM-1 showed a strong antibacterial activity against the tested bacteria. Therefore, the compound ZM-1 is a valuable lead compound for the development of agricultural fungicides while acts against bacteria, as well.
