Author/Authors :
Rafraf Maryam نويسنده Nutritional Research Center, Faculty of Health and Nutrition, Tabriz University of Medical Sciences , Ghaffari Aida نويسنده Liver and Gastrointestinal Disease Research Center, Tabriz University of Medical Sciences , Sepehri Bita نويسنده Fellowship of Gastroenterology, Department of Gastroenterology, Imam Reza Hospital, Tabriz University of Medical Sciences, Tabriz , Asghari-Jafarabadi Mohammad نويسنده Medical Education Research Center, Faculty of Health, Tabriz University of Medical Sciences, Tabriz, Iran , Navekar Roya نويسنده Student Research Committee, Tabriz University of Medical
Sciences, Tabriz, Iran , Ghavami Seyyed-Mostafa نويسنده Department of Radiology, Faculty of Paramedical, Tabriz
University of Medical Sciences, Tabriz, Iran , Manafi Nahid نويسنده Sanjesh Laboratory
Abstract :
Background Elevated levels of homocysteine (Hcy) and fetuin-A are
important risk factors for cardiovascular diseases in patients with a
nonalcoholic fatty liver disease (NAFLD). There is limited evidence
regarding the effects of turmeric on NAFLD. Objectives This study aimed
at investigating the effects of turmeric supplementation on serum levels
of Hcy and fetuin-A in patients with NAFLD. Methods In this
double-blind, randomized, controlled clinical trial, 46 NAFLD patients
(21 males and 25 females; age range, 20 - 60 years) with body mass index
ranged 24.9 - 40 kg/m2 were recruited from
Sheikh-ol-Raees clinic in Tabriz City, Iran during Nov 2014-May 2015.
The participants were allocated into the two groups using the block
randomization method. The intervention and control groups received 3g of
turmeric (n = 23) and placebo (n = 23), daily for 12 weeks. Fasting
blood samples were collected at baseline and at the end of the trial for
biochemical analysis. Results Turmeric supplementation significantly
decreased serum levels of Hcy, compared with the placebo group at the
end of the study (by 27.83%, P = 0.034). No significant difference was
observed between the two groups in serum levels of fetuin-A after the
intervention (P > 0.05). Serum levels of glucose, insulin and
homeostasis model assessment for insulin resistance were declined
significantly in the turmeric group (by 1.22%, 17.69% and 19.48%, P =
0.039, P = 0.013 and P = 0.001, respectively) compared to the placebo.
Conclusions Turmeric consumption had beneficial effects on serum Hcy
levels and may be useful in management of this risk factor in NAFLD
patients.
