Author/Authors :
Karajibani Mansour نويسنده Department of Nutrition, Faculty of Medicine, Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, Iran Karajibani Mansour , Montazerifar Farzaneh نويسنده Department of Nutrition, Faculty of Medicine, Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, Iran Montazerifar Farzaneh , Khazaei Feizabad Abdurrashid نويسنده English Department, School of Medicine, Zahedan University
of Medical Sciences, Zahedan, IR Iran
Abstract :
Context This study was a systematic review that aimed to extract
published articles regarding oxidant and antioxidants status in opium
addiction by searching in PubMed, Google Scholar engine, SID, and
Magiran databases. Evidence Acquisition Sixty-six published articles
were investigated in this review, which were selected from studies among
the Iranian society and other societies from 1976 to 2015. All articles
published in different fields of descriptive-analytical, experimental,
and interventional studies were considered. Results Several studies have
shown that with increased production of free radicals and reactive
oxygen species (ROS), the enzymatic and non-enzymatic antioxidants such
as glutathione (GSH) and glutathione peroxidase (GPx), superoxide
dismutase (SOD), and catalase activities, and also the concentration of
vitamins A, E, C and total antioxidant capacity (TAC) decrease in opium
addiction. Increased atherogenic indexes such as Low density
lipoprotein/high density lipoprotein (LDL/HDL) ratio and malondialdehyde
(MDA) may contribute to the increased risk of cardiovascular disease.
However, it has also increased other markers of oxidative stress
including: isoprostanes, 8-oxoguanine and protein carbonyl. Conclusions
Oxidative stress increases in opium-addicted people. It seems that opium
is capable of provoking oxidative stress and also, has harmful effects
on lipid profile and antioxidant enzyme. Drug addicts were found to have
antioxidant vitamin deficiency.
