Author/Authors :
Namayandeh Seyedeh Mahdieh نويسنده , Soltani Mohammad Hossein نويسنده , Faraji Reza نويسنده Department of Parasitology and Mycology, Kermanshah University of Medical Sciences, Kermanshah, Iran Faraji Reza , Mirzaei Masoud نويسنده Department of Chemistry, Ferdowsi University of Mashhad, P.O. Box 91779-1436 Mashhad, I.R. IRAN , Salehi-Abargouei Amin نويسنده Food Security Research Center, Isfahan University of Medical Sciences, Isfahan , Sarebanhassanabadi Mohammadtaghi نويسنده Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. , Baramesipour Zahra نويسنده Department of Psychology, Yazd Science and Research Branch, Islamic Azad University, Yazd, Iran. 2. Department of Psychology, Yazd Branch, Islamic Azad University, Yazd, Iran. , Jalil Mirhosseini Seyed نويسنده Associate Professor of Cardiovascular Surgery, Yazd
Cardiovascular Research Center, Shahid Sadoughi University of
Medical Sciences, Yazd, Iran , Pedarzadeh Ali نويسنده Assistant Professor in Cardiology, Yazd Cardiovascular
Research Center, Shahid Sadoughi University of Medical Sciences,
Yazd, Iran
Abstract :
Background Metabolic Syndrome (MetS) is rapidly growing in
todayʹs world as an important predictor for type 2 diabetes and
cardiovascular disease. Objectives The present study aimed at assessing
the incidence of MetS and the most powerful components as predictors of
MetS in a cohort study in central Iran. Methods This cohort study was a
follow-up of participants (n = 2000 and aged 20 to 74 years), who were
selected using multistage random cluster sampling method from urban
areas of Yazd, Iran, during year 2005 and repeated in 2015. Metabolic
Syndrome was defined using a modified version of National cholesterol
education program adult treatment panel III (NCEP III) definition. To
assess hazard ratio of components of MetS for crude and adjusted values
in two models, Cox proportional hazard regression was used. Results
Prevalence of MetS was 44.8% (n = 887) at baseline. Therefore, we
followed subjects without MetS (n = 809) in 2015. After about 10 years,
MetS was developed in 56.1% (n = 454) of subjects. Incidence of MetS in
males and females was 56.1/1000 person-years and 58.7/1000 person-years,
respectively. The analysis revealed that incidence of MetS significantly
increased with age and higher level of socio-economic status and
decreased with high level of education. In females and males the most
powerful component for incidence of MetS was high fasting blood glucose
(HR = 16.6, 95% CI: 1.91 - 22.82) and hypertriglyceridemia (HR = 1.64,
95% CI: 1.02 - 2.6), respectively. Conclusions The current study showed
a high incidence of MetS in males and females residing in central Iran.
Furthermore, community-based interventions that reduce MetS in the
population are needed.
