Author/Authors :
Molaei Mahsa نويسنده , Kazerouni Faranak نويسنده Department of Laboratory Medicine, Faculty of Paramedical Sciences, Shahid Beheshti University, MC, Tehran , Nazemalhosseini Mojarad Ehsan نويسنده Gastroenterology and Liver Disease Research Center, Shahid Beheshti University of Medical Sciences, Tehran , Asadzadeh Aghdaei Hamid نويسنده Basic and Molecular epidemiology of Gastrointestinal Disorders Research Center, Shahid Beheshti University Medical Sciences, Tehran , Navidinia Masoumeh نويسنده Department of Medical Bacteriology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, IR Iran , Rahimipour Ali نويسنده Proteomics Research Center, Faculty of Paramedical Sciences , Samadi Roghaieh نويسنده Endocrine Physiology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract :
Objectives Overexpression of human leukocyte antigen G (HLA-G) in
several malignant tumors has been reported. The aim of our study was to
investigate HLA-G expression in colorectal cancer tumors and determine
HLA-G expression relation between clinico-pathological characteristics
and survival time. Methods HLA-G expression was evaluated by
immunohistochemistry (IHC) using anti-HLA-G antibody in 100 primary
tumors of colorectal cancer with different stages. Results Our results
showed that 25% of the colorectal cancer tissues had positive HLA-G
expression and 75% no stained with anti-HLA-G antibody. The HLA-G
expression in advanced stages (III and IV) was more prevalent than those
in earlier clinical stages (I and II) (P = 0.0001). Results showed that
HLA-G expression can serve as an independent factor for overall survival
(OS). In this study, patients with HLA-G expression had significantly
shorter survival time than those with negative expressions (P = 0.023).
Conclusions HLA-G expression can serve as an independent factor for OS
and its expression may be directly related to aggressive tumor behavior
via escape from the host antitumor immune defense. Protein expression of
HLA-G correlates with poor prognosis in colorectal cancer.
