Author/Authors :
Sayehmiri Kourosh نويسنده Department of Social Medicine, Prevention of Psychosocial Injuries Research Centre, Ilam University of Medical Sciences, Ilam, Iran Sayehmiri Kourosh , Alikhani Mohammad Yousef نويسنده Department of Microbiology, Faculty of Medicine, Hamedan University of Medical Sciences, Hamedan, IR Iran , Karami Manoochehr نويسنده Department of Biostatistics and Epidemiology, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran , Sayehmiri Fatemeh نويسنده The Student Research Committee, Ilam University of Medical Sciences, Ilam, Iran , Ghaderkhani Jalal نويسنده Department of Epidemiology, Hamadan University of Medical Sciences, Hamadan, IR Iran
Abstract :
[Background]Acinetobacter baumannii is one of the most important opportunistic pathogens responsible for several nosocomial infections. A major problem in treatment is antibiotic resistance.[Methods]By searching international and national databases, including PubMed, Google Scholar, Web of Science, SID, Magiran, IranDoc and IranMedex, 38 articles between years 2002 to 2016 published world-wide were extracted and analyzed using the meta-analysis method and random effects model. The heterogeneity of studies was assessed using the I2 index. Data were analyzed with the R and STATA (Ver 11/2) software.[Results]Forty-three articles were selected for this study. Drug-resistance of Acinetobacter baumannii towards Polymyxin was reported as 5%, yet for Colistin 4% was estimated. Resistance rates to Polymyxin and Colistin in the continent of America and Asia was 6% and Sensitivity rate to Polymyxin and Colistin was 96% and 80%, respectively.[Conclusions]Given that drug resistance rate of Acinetobacter baumannii to Polymyxin and Colistin in this study was 5% and 4%, respectively, thus indicating high sensitivity of Acinetobacter baumannii to these antibiotics, this group can be administered as appropriate therapeutic agents against these bacteria.
