Author/Authors :
Kazerouni Faranak نويسنده Department of Laboratory Medicine, Faculty of Paramedical Sciences, Shahid Beheshti University, MC, Tehran , Dehghan Nayeri Nasrin نويسنده Department of Proteomics, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran , Bakhshandeh Mohsen نويسنده Department of Radiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran , Bakhshi Mostafa نويسنده , Ebrahimi Firouz نويسنده Biology Research Center, Basic Sciences Faculty, Imam Hossein University (IHU), Tehran, IR Iran , Samadi Roghaieh نويسنده Endocrine Physiology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran , Zarei Hamed نويسنده Radiology Technology Department, School of Allied Medical Health, Shahid Beheshti University of Medical Sciences. Tehran, Iran , Mozdarani Hossein نويسنده Department of Medical Genetics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran , Mahmoudzadeh Aziz نويسنده Department of BioScience and Biotechnology, Malek-Ashtar University of Technology, Tehran, Iran , Zeynalian Hoda نويسنده Department of Laboratory Medicine, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran , Rahimipour Ali نويسنده Radiology Technology Department, School of Allied Medical Health, Shahid Beheshti University of Medical Sciences. Tehran, Iran
Abstract :
The most important problem with radiotherapy is the limitation of whole body irradiation of a metastatic patient. There are evidence showing that similar effect will occur in non-irradiated tumors similar to the irradiated ones. This effect is called abscopal effect. In the present study, the abscopal effect on local induced mice breast cancers has been investigated. One million of 4T1 mice breast cancer cell line was injected to balb/c mice subcutaneously while being under anesthesia. After the growth of tumors till becoming palpable, one of two induced tumors were exposed to total 28 Gy, with gamma rays emitted from a cobalt -60 tele-therapy machine in 14 fractions with 2 Gy daily doses. Tumor volumes were measured, using the caliper. The data was analyzed by the use of non-parametrical and ANOVA tests. Similar growth in non-irradiated control tumors was seen. After 10 or 11 fractions of one- side irradiation and total dose of 20 to 22 Gy, however, non-irradiated tumors, similar to irradiated ones, showed similar effect, reduction of size and volume different from control groups (P < 0.05).The reduction of non-irradiated tumors relative to irradiation of another tumor in the same mouse is the emblem of occurrence of the abscopal effect. The mechanism of the abscopal effect is unknown but it could be related to the release of cytokines from irradiated tumors with their receptors existing on the surface of non-irradiated tumors. By induction of this effect, the remission probability of small metastases after local irradiation could be possible
