Possible role interaction between cannabinoid and TRPC3, TRPC6 and TRPV2 in behavioral process

Most studies have found that changes in concentration of intracellular ions can change cell activation. Calcium ion is one of the most vital one of these ions which is the most vital second messenger within cells. Ca2+ is necessary for a wide range of cellular processes such as cell proliferation, muscle contraction and exocytosis and apoptosis. Different kinds of TRPCs (transient receptor potential cation channels) have a wide range of activity in cell but are known as Ca2+ blocker channel. On the other hand, cannabinoids are a class of different chemical compounds that act on cannabinoid receptors in cells that suppress neurotransmitter release in the brain. Ligands for these receptor proteins consist of endocannabinoids (produced naturally in the body of humans and animals), the phytocannabinoids (exist in cannabis and some other plants), and synthetic cannabinoids (artificially made). The most important cannabinoid is the phytocannabinoid tetrahydrocannabinol (THC), the primary psychoactive compound of cannabis. Cannabidiol (CBD) is another major part of the plant. It is showed that endocannabinoid biosynthesis is a calcium-dependent process, though the physiological source of calcium is not identified. Many of biochemical experiments have been investigating the contributions of extracellular and intracellular calcium in the biosynthetic process. Some studies found that extracellular calcium is a vital factor for the endogenous cannabinoids biosynthesis, while a simply releasing intracellular calcium store such as endoplasmic reticulum does not have an effect on endocannabinoid biosynthesis. In addition to introduction of cannabinoid, blocker of Ca2+ channel (TRPC) and investigating interaction among them in this review, the possible role of cannabinoid and TRPC3, TRPC6 and TRPV2 in behavioral process are induced in conclusion.