Author/Authors :
Nematy Mohsen نويسنده Department of Nutrition, Biochemistry of Nutrition, Endoscopic & Minimally Invasive Surgery, and Cancer Research Centers, School of Medicine, Mashhad , Taghipour Ali نويسنده , Ganji Azita نويسنده , Azimi-Nezhad Mohsen نويسنده Université de Lorraine, Unité de Recherche “Interactions Gène-Environnement en Physiopathologie CardioVasculaire” l’UMR INSERM U 1122, IGE-PCV, Nancy, France Azimi-Nezhad Mohsen , Mohebbi Dehnavi Zahra نويسنده Department of Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran , Razmpour Farkhonde نويسنده Departments of Nutrition, School of Medicine, Mashhad
University of Medical Sciences, Mashhad, Iran , Belghaisi Naseri Mahmoud نويسنده MSC Student of Nutrition Science, Department of Nutrition,
Mashhad University of Medical Sciences (MUMS), Mashhad,
Iran , Vatanparast Hasan Ali نويسنده MD, PhD, Associated Professor in Nutrition Science,
College of Pharmacy and Nutrition, Saskatchewan University of Health
Science, Saskatchewan, Canada , Alamdaran Seyed Ali نويسنده MD, Associated Professor of Radiology, Department of
Radiology, Mashhad University of Medicine Sciences (MUMS), Mashhad,
Iran
Abstract :
Context Nonalcoholic fatty liver disease (NAFLD) is increasing
with the increased rate of obesity and reduced physical activity in
children worldwide. Despite high prevalence of the disease, a standard
and acceptable diagnostic method is not available. The current study
aimed at collecting all related articles and evaluating the challenges.
Methods The current study searched Scopus, Web of Science, and PubMed.
Articles and guidelines in English in the field of invasive and
noninvasive diagnostic methods for NAFLD and nonalcoholic
steatohepatitis (NASH) in children and adolescents up to Oct 2016 were
used. It was tried to evaluate all laboratory and radiologic methods,
biomarkers, and scores in addition to mention the challenges. Results
Ultrasonography and laboratory evaluation, which were routine methods in
early diagnosis, did not have enough accuracy in this field. Diagnosis
of steatosis and fibrosis and determining the severity of disease were
achieved by fibro scan and controlled attenuation parameter (CAP)
without the challenges of computed tomography (CT) scan and magnetic
resonance imaging (MRI). Fatty liver can be predicted with high accuracy
by body analyzer, anthropometric, and DEXA methods. Conclusions
Diagnosis and prediction of fatty liver should be done in all children
with obesity aged > 3 years, and physician should seek the
genetic and metabolic causes in children aged < 3 years and/or
without overweight.
