Author/Authors :
Shabani Mohammad نويسنده Department of Neuroscience, Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran Shabani Mohammad , Sheibani Vahid نويسنده Neuroscience Research Center, Kerman University of Medical Sciences, Kerman , Mirnajafi-zadeh Javad نويسنده Physiology Department, Faculty of Medicine, Tarbiat Modares University, Tehran, Iran. Mirnajafi-zadeh Javad , Esmaeilpour Khadijeh نويسنده Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran. Esmaeilpour Khadijeh , Akbarnejad Zeinab نويسنده Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran. Akbarnejad Zeinab
Abstract :
Introduction: The life quality of patients with epileptic seizures is highly affected by cognitive deficits. Low Frequency Stimulation (LFS) is a novel approach for the treatment of pharmacoresistant epilepsy. The main goal of this research is investigating the possible effect of LFS on seizure-induced cognitive dysfunction.amp;nbsp;
Methods: To this end, the kindled animal were prepared via CA1 electrical stimulation in a semi-rapid way (12 stimulations/day). A group of animals were stimulated with LFS, 4 times at 30 s, 6 h, 24 h, and 30 h after the last kindling stimulation. Applied LFS was administered in 4 packages every 5 minutes.amp;nbsp; The packages were designed with 200 monophasic 200 monophasic square wave pulses of 0.1 ms duration at 1 Hz. The passive-avoidance test was conducted on all animals in order to measure the learning and memory behavior.
Results: Hippocampal kindled rats showed deficits in learning and memory when passive avoidance test was performed. Application of LFS reversed the impairment in learning and memory behavior in kindled rats. At the same time, LFS markedly diminished kindling-induced neuronal loss and atrophy in the hippocampus.
Conclusion: LFS may have some protection against seizure-induced cognitive damage in kindled rats.
