Author/Authors :
Pourshams Akram نويسنده , Besharat Sima نويسنده Department of Obstetrics and Gynecology, Faculty of Medicine, Shahed University of Medical Sciences, Tehran, Iran , Poustchi Hossein نويسنده Digestive Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran Poustchi Hossein , Mohamadkhani Ashraf نويسنده Digestive Disease Research Centre, Shariati Hospital, Tehran University of Medical Science, Tehran, Iran , Roshandel Gholamreza نويسنده Liver and Pancreatobiliary Diseases Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, IR Iran Roshandel Gholamreza , Gol-Jah Rad Golnosh نويسنده Liver and Pancreatobiliary Diseases Research Center,
Digestive Diseases Research Institute, Tehran University of Medical
Sciences, Tehran, Iran , Pour Dadash Asiabar Akbar نويسنده Microbiology Laboratory, Dr. Shariati Hospital, Tehran,
Iran
Abstract :
Background Loss of hepatitis B surface antigen (HBsAg) in chronic
hepatitis B (CHB) infection is a favorable outcome. Type I interferon
(IFNI) has an essential role to fight virus infections when they bind to
the IFN-α/β receptor (IFNAR). Free-circulating IFNARs, known as IFNAR2,
perform as carrier proteins to keep the ligands from proteolysis as well
as antagonists for ligand binding. Objectives In this study, we
evaluated the HBsAg titer and IFNAR2 in serum baseline of a subcohort of
Iranian HBeAg-negative patients with chronic hepatitis B. Methods
Sixty-four patients who spontaneously cleared HBsAg and 100 chronic
hepatitis B patients enrolled in this study for assessment of the serum
levels of HBsAg and IFNAR2. Results Serum levels of HBsAg and IFNAR2
were both powerfully associated with loss of HBsAg. The baseline HBsAg
titer was significantly lower (333.72 ± 1300 IU/mL vs 3811 ± 6779 IU/mL,
P = 0.00) and the IFNAR2 serum level was significantly higher (1.64 ±
0.6 vs 0.87 ± 0.5 ng/mL, P = 0.00) in those who cleared HBsAg compared
to the CHB patients. Conclusions These findings indicated the
association of the HBsAg titer and serum IFNAR2 in HBsAg clearance in
hepatitis B virus- infected patients. In consequence, immune mechanisms
related to IFN-α/β signaling might be responsible in CHB outcome.
